2-Amino-4-(p-nitrophenyl)thiazole → 2-Amino-4-(4-aminophenyl)thiazole

HRID 1637927Notes

Reaction equation

HRID 1637927 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=2)[N:6]=1>CN(C=O)C>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:8]=[CH:9][C:10]([NH2:13])=[CH:11][CH:12]=2)[N:6]=1

Participants

3

Reactant 1

HCID 164202-Amino-4-(p-nitrophenyl)thiazole

Product 1

HCID 6055642-Amino-4-(4-aminophenyl)thiazole

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared by 2 hours' hydrogenation of 2-amino-4-(4-nitro-phenyl)-thiazole (melting point: 287-291° C.; prepared from ω-bromo-4-nitro-acetophenone and thiourea) in DMF on palladium/charcoal (10%) at 20° C.

Sources & evidence

ORD record
ord-be4ae694ac25499fa8fc165414f891c9
Source dataset
uspto-grants-2000_03
Patent number
US06043254

Reaction notes

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