Ethanol → HCID 54527564, compound

HRID 1637933Notes

Reaction equation

HRID 1637933 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][CH:17]=1)[CH:7]=[C:8]1[NH:12][C:11](=[O:13])[NH:10][C:9]1=[O:14])([O-])=O.NC1SC=C(C2C=CC(N)=CC=2)N=1.CCO>CN(C=O)C.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][CH:17]=1)[CH:7]=[C:8]1[NH:12][C:11](=[O:13])[NH:10][C:9]1=[O:14]

Participants

6

Reactant 3

HCID 702EthanolHCID 3778255-(3-nitrobenzylidene)imidazolidine-2,4-dioneHCID 6055642-Amino-4-(4-aminophenyl)thiazole

Product 1

HCID 54527564HCID 54527564, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 6228DimethylformamideSolvent

Procedure

2.3 g (10 mmol) of crude 3-nitro-benzylidene-hydantoin, melting point 280-284° C., (prepared as described in Example 6 in (a)) are hydrogenated in 60 ml of DMF and 40 ml EtOH on 2 g of Raney nickel for 36 hours at 20° C. and 3.5 bar. It is filtered over kieselguhr and the filtrate is evaporated down in vacuo. The evaporation residue is crystallised with ether.

Workup

  1. filtrationIt is filtered over kieselguhr
  2. customthe filtrate is evaporated down in vacuo
  3. customThe evaporation residue is crystallised with ether

Sources & evidence

ORD record
ord-868b03d787424b74b9f08e5b99c7e1e2
Source dataset
uspto-grants-2000_03
Patent number
US06043254

Reaction notes

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