Hydrochloric Acid → HCID 178473760, compound

HRID 1637967Notes

Reaction equation

HRID 1637967 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][C:7]([NH:11]/[C:12](=[C:19]3\[C:20](=[O:31])[NH:21][C:22]4[C:27]\3=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][CH:23]=4)/[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:8][CH:9]=2)[CH2:4][CH2:3][NH:2]1.Cl.[C:33](OC(=O)C)(=[O:35])[CH3:34].CCN(C(C)C)C(C)C>C(O)(=O)C.O>[C:33]([N:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[C:7]([NH:11]/[C:12](=[C:19]3\[C:20](=[O:31])[NH:21][C:22]4[C:27]\3=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][CH:23]=4)/[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:6]=2)[CH2:1]1)(=[O:35])[CH3:34]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 81531DiisopropylethylamineHCID 178517244HCID 178517244, compound

Product 1

HCID 178473760HCID 178473760, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

Prepared from 3-{(Z)-1-[(1,2,3,4-tetrahydro-isoquinolin-6-yl)-amino]-1-phenylmethylidene}-5-nitro-2-indolinone×HCl×H2O in glacial acetic acid with acetic anhydride in the presence of Hunig's base.

Sources & evidence

ORD record
ord-a60451e7c2a44bce8c4c6d5dbac72932
Source dataset
uspto-grants-2000_03
Patent number
US06043254

Reaction notes

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