4-Bromoaniline → HCID 178517246, compound

HRID 1637968Notes

Reaction equation

HRID 1637968 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=2)[C:6](=[C:16](OCC)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:5]1=[O:26])(=O)C.[Br:27][C:28]1[CH:34]=[CH:33][C:31]([NH2:32])=[CH:30][CH:29]=1>CN(C=O)C>[Br:27][C:28]1[CH:34]=[CH:33][C:31]([NH:32]/[C:16](=[C:6]2\[C:5](=[O:26])[NH:4][C:12]3[C:7]\2=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=3)/[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:30][CH:29]=1

Participants

4

Reactant 2

HCID 78074-BromoanilineHCID 542801041-Acetyl-3-{1-ethoxy-1-phenylmethylidene}-5-nitro-2-indolinone

Product 1

HCID 178517246HCID 178517246, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared by reacting 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-nitro-2-indolinone with 1.5 equivalents of 4-bromo-aniline in DMF (110° C., for 2 hours), subsequent treatment with piperidine (20° C., 0.5 hours) and precipitation with water.

Workup

  1. customPrepared
  2. customwith piperidine (20° C., 0.5 hours) and precipitation with water

Sources & evidence

ORD record
ord-3c70e8a8a84848839e3c65f35dae0f8d
Source dataset
uspto-grants-2000_03
Patent number
US06043254

Reaction notes

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