Hydrochloric Acid → HCID 178478664, compound

HRID 1638136Notes

Reaction equation

HRID 1638136 reaction equation
[ClH:1].Cl.C(OC([N:10]1[CH2:16][CH2:15][C:14](=[NH:17])[NH:13][CH2:12][CH2:11]1)=O)(C)(C)C>C(OCC)(=O)C>[ClH:1].[ClH:1].[NH:17]=[C:14]1[CH2:15][CH2:16][NH:10][CH2:11][CH2:12][NH:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178452345HCID 178452345, compound

Product 1

HCID 178478664HCID 178478664, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Hydrogen chloride gas (2.0 g, 55 mmol) was bubbled into 15 mL of ethyl acetate at 0° C. over 3 min. 1-(tert-Butoxycarbonyl)-5-iminohexahydro-(1H)-1,4-diazepine hydrochloride (85 mg, 0.34 mmol ) was added and mixture was stirred at room overnight. Removal of solvent and hydrogen chloride in vacuo gave 60 mg (95%) of hexahydro-5-imino-(1H)-1,4-diazepine dihydrochloride as a yellow solid.

Workup

  1. customRemoval of solvent and hydrogen chloride in vacuo

Sources & evidence

ORD record
ord-facd84a9b17e44bc882427911d1b154e
Source dataset
uspto-grants-2000_03
Patent number
US06043358

Reaction notes

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