反应详情

温度

10 °C

N-[(2-chlorophenyl-methyl)]-2-(2-thienyl)ethylamine HCl (14.4 g) is suspended into 50 ml of dimethoxyethane. 1,3-Dithiane (9 g) and 0.12 ml of 37% hydrochloride acid are added. The reaction mixture is refluxed for 24 hours. Thereafter, the mixture is cooled to 10° C. and the crystalline precipitate is filtered and washed twice with 5 ml of dimethoxyethane. The product is dried at 60° C. under vacuum to yield 9.4 g (62.7%) of ticlopidine hydrochloride having the same physico-chemical characteristics as reported in Example 1.

1. temperatureThe reaction mixture is refluxed for 24 hours
2. filtrationthe crystalline precipitate is filtered
3. washwashed twice with 5 ml of dimethoxyethane
4. customThe product is dried at 60° C. under vacuum