2,4-Dichlorophenol → HCID 13849851, compound

HRID 1638245Notes

Reaction equation

HRID 1638245 reaction equation
Cl[CH2:2][C:3](=[O:10])[C:4]([CH2:8][CH3:9])([CH3:7])[CH2:5][CH3:6].C(=O)([O-])[O-].[K+].[K+].[Cl:17][C:18]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=1[OH:25]>CN(C)C=O>[Cl:17][C:18]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=1[O:25][CH2:2][C:3](=[O:10])[C:4]([CH2:8][CH3:9])([CH3:7])[CH2:5][CH3:6]

Participants

5

Reactant 3

HCID 84492,4-DichlorophenolHCID 11430Potassium CarbonateHCID 13849852HCID 13849852, compound

Product 1

HCID 13849851HCID 13849851, compoundYield 93.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

50 g (0.28 mole) of 1-chloro-3-ethyl-3-methyl-pentan-2-one, dissolved in 30 ml of N,N-dimethylformamide, are added to a mixture of 38.6 g (0.28 mole) of potassium carbonate and 45.6 g (0.28 mole) of 2,4-dichlorophenol in 200 ml of N,N-dimethylformamide at the boiling point. The mixture is heated at the boiling point for 10 hours, cooled to room temperature and filtered and the solvent is distilled off under reduced pressure. Distillation of the residue gives 75.7 g (93.5% of theory) of 1-(2,4-dichlorophenoxy)-3-ethyl-3-methyl-pentan-2-one as a color less liquid of boiling point 141°-144° C./0.15 mm. ##STR64##

Workup

  1. temperatureThe mixture is heated at the boiling point for 10 hours
  2. filtrationfiltered
  3. distillationthe solvent is distilled off under reduced pressure
  4. distillationDistillation of the residue

Sources & evidence

ORD record
ord-890431b5284d43069a47065b9451053b
Source dataset
uspto-grants-1989_11
Patent number
US04878939

Reaction notes

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