Ethyl Acetate → HCID 54081862, compound

HRID 1638457Notes

Reaction equation

HRID 1638457 reaction equation
C(OCC)(=O)C.[Cl:7][C:8]1[CH:9]=[C:10]([N:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:18][C:17]2=[O:25])[CH:11]=[CH:12][C:13]=1[O:14][CH3:15].[CH3:26][N:27]1[CH2:31][CH2:30][CH2:29][C:28]1=O>CCOCC>[Cl:7][C:8]1[CH:9]=[C:10]([N:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:18](=[C:28]3[CH2:29][CH2:30][CH2:31][N:27]3[CH3:26])[C:17]2=[O:25])[CH:11]=[CH:12][C:13]=1[O:14][CH3:15]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 13387N-methyl-2-pyrrolidoneHCID 13339543HCID 13339543, compound

Product 1

HCID 54081862HCID 54081862, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

By the procedure of Example B1, except that ethyl acetate was used as eluant and ether to crystallize the product, 1-(3-chloro-4-methoxyphenyl)-2(1H,3H)-indolone (1.05 g, 3.84 mole) and N-methyl-2-pyrrolidone (0.62 ml, 6.42 mmoles) were converted to title product, 0.58 g, m.p. 126°-127.5°.

Sources & evidence

ORD record
ord-910cc0322e3445d6af59459b3a65e952
Source dataset
uspto-grants-1989_11
Patent number
US04879391

Reaction notes

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