N-methyl-2-pyrrolidone → HCID 54418606, compound

HRID 1638458Notes

Reaction equation

HRID 1638458 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12][C:11]2=[O:19])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[CH3:20][N:21]1[CH2:25][CH2:24][CH2:23][C:22]1=O>C(OCC)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12](=[C:22]3[CH2:23][CH2:24][CH2:25][N:21]3[CH3:20])[C:11]2=[O:19])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

Participants

4

Reactant 2

HCID 13387N-methyl-2-pyrrolidoneHCID 13339542HCID 13339542, compound

Product 1

HCID 54418606HCID 54418606, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

By the procedure of Example B5, except to use ethyl acetate as eluant, 1-(3-fluoro-4-methoxyphenyl)-2(1H,3H)-indolone (2.0 g, 7.8 mmoles) and 1-methyl-2-pyrrolidone (1.5 ml, 15.6 mmole) were converted to title product, 0.32 g, m.p. 68°-71°.

Sources & evidence

ORD record
ord-f6f559a1d3f1459f84c3247b9c600d80
Source dataset
uspto-grants-1989_11
Patent number
US04879391

Reaction notes

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