Methyl formate → HCID 70395556, compound

HRID 1639007Notes

Reaction equation

HRID 1639007 reaction equation
[CH3:1][O:2][C:3](=[O:18])[CH2:4][N:5]([C:7](=[O:17])[CH:8]=[CH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[Cl:16])[CH3:6].[H-].[Na+].[CH:21](OC)=[O:22]>>[Cl:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[CH:9]=[CH:8][C:7]([N:5]([CH3:6])[C:4](=[CH:21][OH:22])[C:3]([O:2][CH3:1])=[O:18])=[O:17]

Participants

4

Reactant 3

HCID 7865Methyl formateHCID 24758Sodium hydrideHCID 54296671HCID 54296671, compound

Product 1

HCID 70395556HCID 70395556, compound

Procedure

By a procedure analogous to that described in Example 1, part of the crude N-(o-chlorocinnamoyl)sarcosine methyl ester (6.99 g), methyl formate (30 ml) and sodium hydride (2.35 g) gave methyl N-(o-chlorocinnamoyl)-N-methyl-2-amino-3-hydroxypropenoate (4.56 g) as an off-white solid, m.p. 129°-130° C.

Sources & evidence

ORD record
ord-168b6f0f9a984f0cbca9a29f0f0cd290
Source dataset
uspto-grants-1989_11
Patent number
US04882341

Reaction notes

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