反应详情

温度

60 °C

A mixture of 0.4 g of 5-hydroxy-pyrrolidin-2-one, 10 cm3 of n-hexanol and 0.2 g of Amberlite IR 120H is heated to 60° C. for 3 hours. The solvent is distilled off at 25° C. under 0.3 mbar. The residue is chromatographed on silica (eluent: ethyl acetate); 0.5 g of the residue is crystallized from hexane, and the expected product is obtained, m.p. 35°-37° C.

1. distillationThe solvent is distilled off at 25° C. under 0.3 mbar
2. customThe residue is chromatographed on silica (eluent: ethyl acetate)
3. custom0.5 g of the residue is crystallized from hexane