Heptanol → 5-(n-Heptyloxy)-pyrrolidin-2-one

HRID 1639047Notes

Reaction equation

HRID 1639047 reaction equation
[OH:1][CH:2]1[NH:6][C:5](=[O:7])[CH2:4][CH2:3]1.[CH2:8](O)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]>>[CH2:8]([O:1][CH:2]1[NH:6][C:5](=[O:7])[CH2:4][CH2:3]1)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

Participants

3

Reactant 2

HCID 8129HeptanolHCID 1941485-Hydroxy-2-pyrrolidone

Product 1

HCID 156965645-(n-Heptyloxy)-pyrrolidin-2-one

Conditions

Temperature
60 °C

Procedure

A mixture of 8 g of 5-hydroxy-pyrrolidin-2-one, 100 cm3 of n-heptanol and 4 g of Amberlite IR 120H is heated to 60° C. for 4 hours, filtered, then the solvent is eliminated under 0.3 mbar at 45° C./60° C. 11.9 g of the expected product is obtained, m.p. 52°-54° C., crystallized from hexane.

Workup

  1. filtrationfiltered
  2. customis eliminated under 0.3 mbar at 45° C.
  3. custom60° C

Sources & evidence

ORD record
ord-f5ce86bcbe26430bb9df71d5e24a01fe
Source dataset
uspto-grants-1989_11
Patent number
US04882350

Reaction notes

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