1-Butanol → HCID 14422895, compound

HRID 1639086Notes

Reaction equation

HRID 1639086 reaction equation
[Cl:1][CH2:2][CH2:3][CH:4]([OH:16])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1.[C:17]1([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(=O)([O-])[O-].[Na+].[Na+].C(O)CCC>Cl>[ClH:1].[ClH:1].[N+:13]([C:10]1[CH:11]=[CH:12][C:7]([O:6][CH2:5][CH:4]([OH:16])[CH2:3][CH2:2][N:26]2[CH2:27][CH2:28][N:23]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:24][CH2:25]2)=[CH:8][CH:9]=1)([O-:15])=[O:14]

Participants

6

Reactant 4

HCID 2631-ButanolHCID 70961-PhenylpiperazineHCID 10340Sodium CarbonateHCID 14422832HCID 14422832, compound

Product 1

HCID 14422895HCID 14422895, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

This compound was prepared according to the procedure of Example 25. A mixture of 12.3 g (0.05 mole) of 4-chloro-1-(4-nitrophenoxy)-2-butanol, 8.1 g (0.05 mole) of 1-phenylpiperazine, and 26.0 g (0.25 mole) of anhydrous sodium carbonate in a total volume of 250 ml of 1-butanol gave a golden oil as residue. The hydrochloride was formed in ethereal hydrogen chloride and the collected solid was recrystallized thrice from methanol-water to give 1.1 g (5%) of white solid, m.p. 195°-200° C.

Workup

  1. customThis compound was prepared
  2. customgave a golden oil as residue

Sources & evidence

ORD record
ord-48ad545c80d64ae0b07b5b7f028ce923
Source dataset
uspto-grants-1989_11
Patent number
US04882330

Reaction notes

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