Potassium Iodide → HCID 15631760, compound

HRID 1639110Notes

Reaction equation

HRID 1639110 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.Cl[CH2:14][CH2:15][CH:16]([OH:29])[CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=1.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>C(O)CCC>[F:26][C:25]([F:27])([F:28])[C:21]1[CH:20]=[C:19]([CH:24]=[CH:23][CH:22]=1)[O:18][CH2:17][CH:16]([OH:29])[CH2:15][CH2:14][N:10]1[CH2:9][CH2:8][N:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH2:12][CH2:11]1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 944591-(2-Pyridyl)piperazineHCID 131203482-Butanol, 4-chloro-1-[3-(trifluoromethyl)phenoxy]-

Product 1

HCID 15631760HCID 15631760, compoundYield 35.4%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

This compound was prepared according to the procedure used to synthesize the compound of Example 6. A mixture of 3.3 g (0.02 mole) of 1-(2-pyridyl)piperazine, 5.4 g (0.02 mole) of 4-chloro-1-(3-trifluoromethylphenoxy)-2-butanol, 6.4 g (0.06 mole) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 ml of 1-butanol gave 2.8 g (35%) of the title compound as an off-white solid, m.p. 81°-81.5° C. Recrystallizing solvent used was isopropyl ether.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-48fde442d7ba478bb398f0ae4f84d1aa
Source dataset
uspto-grants-1989_11
Patent number
US04882330

Reaction notes

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