Hydrochloric Acid → HCID 19840340, compound

HRID 1639141Notes

Reaction equation

HRID 1639141 reaction equation
C([NH:4][CH2:5][C:6]([C:9]1[CH:18]=[CH:17][C:12]2[N:13]=[C:14]([CH3:16])[NH:15][C:11]=2[CH:10]=1)([CH3:8])[CH3:7])(=O)C.Cl>C(O)C>[NH2:4][CH2:5][C:6]([C:9]1[CH:18]=[CH:17][C:12]2[N:13]=[C:14]([CH3:16])[NH:15][C:11]=2[CH:10]=1)([CH3:8])[CH3:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19840389HCID 19840389, compound

Product 1

HCID 19840340HCID 19840340, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.4 g. 5-(2-acetamidomethylpropan-2-yl)-2-methylbenzimidazole (prepared in Example 29) are boiled under reflux for 24 hours in 60 ml. ethanol and 60 ml. concentrated hydrochloric acid. The solvent is then removed in a vacuum, the residue is neutralised with 2N aqueous ammonia solution and the organic phase is dried over anhydrous sodium sulphate. After filtration and evaporation, there is obtained 0.87 g. of the title compound in the form of an oil.

Workup

  1. temperatureunder reflux for 24 hours in 60 ml
  2. customThe solvent is then removed in a vacuum
  3. dry with materialthe organic phase is dried over anhydrous sodium sulphate
  4. filtrationAfter filtration and evaporation
  5. customthere is obtained 0.87 g

Sources & evidence

ORD record
ord-ed6cd49a276c4f308b26233155146bb8
Source dataset
uspto-grants-1989_11
Patent number
US04882342

Reaction notes

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