反应详情

A stirred slurry containing pyrrolo[1,2-b]cinnolin-10(5H)-one (4.0 g) and potassium carbonate (11.2 g) in 100 ml of 2-butanone was treated with benzyl bromide (4.0 g) and the mixture was stirred at 60°. After 4 h the mixture was quenched with 700 ml of H2O and extracted with two 150 ml portions of dichloromethane. These organic extracts were dried over MgSO4, filtered and concentrated to a green oil. This oil was purified by flash chromatography (silica, dichloromethane) to a yellow solid which was recrystallized from dichloromethane to give 3.5 g of bright yellow crystals, mp 146°-148°.

1. customAfter 4 h the mixture was quenched with 700 ml of H2O
2. extractionextracted with two 150 ml portions of dichloromethane
3. dry with materialThese organic extracts were dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated to a green oil
6. customThis oil was purified by flash chromatography (silica, dichloromethane) to a yellow solid which
7. customwas recrystallized from dichloromethane