反应详情

温度

50 °C

100 mg (0.63 mmol) of 3,4-difluoronitrobenzene, 93.1 mg (0.63 mmol) of 3-methyl-1H-indazol-4-ol (from example I) and 95.6 mg (0.69 mmol) of potassium carbonate are suspended in 5 ml of anhydrous dimethylformamide and stirred at 50° C. for five hours. The reaction solution is then diluted with water and extracted twice with ethyl acetate. The combined organic phases are dried over sodium sulfate. The solvent is removed under reduced pressure and the residue is purified by column chromatography. The mobile phase used is a mixture of cyclohexane and ethyl acetate (1:1).

1. extractionextracted twice with ethyl acetate
2. dry with materialThe combined organic phases are dried over sodium sulfate
3. customThe solvent is removed under reduced pressure
4. customthe residue is purified by column chromatography
5. additiona mixture of cyclohexane and ethyl acetate (1:1)