Trifluoroacetic acid → HCID 178486789, compound

HRID 1639615Notes

Reaction equation

HRID 1639615 reaction equation
[CH3:1][O:2][C:3]1[C:32]([O:33][CH3:34])=[CH:31][C:6]2[NH:7][C:8]([C:10]3[C:14]([NH:15][C:16]([CH:18]4[O:23][CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19]4)=[O:17])=[CH:13][NH:12][N:11]=3)=[N:9][C:5]=2[CH:4]=1.C1(OC)C=CC=CC=1.[F:43][C:44]([F:49])([F:48])[C:45]([OH:47])=[O:46]>ClCCl>[F:43][C:44]([F:49])([F:48])[C:45]([OH:47])=[O:46].[CH3:34][O:33][C:32]1[C:3]([O:2][CH3:1])=[CH:4][C:5]2[NH:9][C:8]([C:10]3[C:14]([NH:15][C:16]([CH:18]4[O:23][CH2:22][CH2:21][NH:20][CH2:19]4)=[O:17])=[CH:13][NH:12][N:11]=3)=[N:7][C:6]=2[CH:31]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 178486790HCID 178486790, compound

Product 1

HCID 178486789HCID 178486789, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-[3-(5,6-dimethoxy-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-rac-4-BOC-2-morpholine carboxamide (65 mg, 0.14 mmol) and anisole (60 μl, 0.56 mmol) were dissolved in a mixture of trifluoroacetic acid and dichloromethane (1:1; 2 ml). After 3 hours at room temperature, the mixture was evaporated to dryness to give N-[3-(5,6-dimethoxy-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-rac-2-morpholine carboxamide-trifluoroacetic acid salt (73 mg) as a colourless solid (LC/MS (acidic method): Rt 1.42 min, [M−H+]− 371.

Workup

  1. customthe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-cb0c06938ea34d6a8bb89bde6b0a95e9
Source dataset
uspto-grants-2012_02
Patent number
US08110573B2

Reaction notes

Loading…