反应详情

To a mixture of potassium hydroxide (16.7 g) and dry DMSO (150 mL), pyrrole (5 g) was added dropwise at 20-25° C., with stirring under nitrogen atmosphere. Stirring was continued for 1 hr at 20-25° C. Ethyl bromoacetate (24.5 g) was added dropwise at 20-25° C. and stirring was continued for 2 hr. In the reaction mixture (150 mL) DM water was added and pH was made acidic (pH=3) with 20% HCl (50 mL). The reaction mixture was extracted with diethyl ether (2×100 mL). The combined organic extract was washed with DM water (100 mL), saturated brine (100 mL) and dried over Na2SO4. The solvent was evaporated to obtain pyrrol-1-yl-acetic acid.

1. additionwas added dropwise at 20-25° C.
2. stirringStirring
3. stirringstirring
4. waitwas continued for 2 hr
5. extractionThe reaction mixture was extracted with diethyl ether (2×100 mL)
6. extractionThe combined organic extract
7. washwas washed with DM water (100 mL), saturated brine (100 mL)
8. dry with materialdried over Na2SO4
9. customThe solvent was evaporated