Chloride → Methyl 2-chloro-5-ethylthiazole-4-carboxylate

HRID 163981Notes

Reaction equation

HRID 163981 reaction equation
[Cl-:17].[Cu:25][Cl:26].[N:1]([O-:2])=[O:3].[NH2:5][c:6]1[s:7][c:8]([CH2:15][CH3:16])[c:9]([C:11](=[O:12])[O:13][CH3:14])[n:10]1.[Na+:18].[Na+:4].[OH2:24].[S:19](=[O:20])(=[O:21])([OH:22])[OH:23]>>[c:6]1([Cl:17])[s:7][c:8]([CH2:15][CH3:16])[c:9]([C:11](=[O:12])[O:13][CH3:14])[n:10]1

Participants

8

Reactant 7

HCID 312ChlorideHCID 923Sodium ion2×HCID 946NitriteHCID 962WaterHCID 1118Sulfuric AcidHCID 62652Cuprous chlorideHCID 737585Methyl 2-amino-5-ethyl-1,3-thiazole-4-carboxylate

Product 1

HCID 59266587Methyl 2-chloro-5-ethylthiazole-4-carboxylate

Sources & evidence

ORD record
ord-43160a1d98f541b18a4e592c2b66345f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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