反应详情

温度

-10 °C

Add dropwise, while stirring, a solution of 37 g (192 mmol) of (2E)-3-(2,6-dimethoxyphenyl)acrylaldehyde and 85.7 g (664 mmol) of ethyl 2-azidoacetate in 200 mL of absolute ethanol EtOH to a solution of 15.5 g (673 mmol) of sodium in 500 mL of absolute EtOH cooled to −10° C. and kept under argon, maintaining the temperature at −10° C. After stirring at −10° C. for 3 h, stir the reaction mixture for 15 h at RT, then pour into 600 mL of an aqueous solution of ammonium chloride (NH4Cl) at 30 wt. %. After filtration on a frit and rinsing with 2×200 mL of water, take up the precipitate in 600 mL of DCM, dry over Na2SO4 and concentrate under reduced pressure, which leads to 42 g of ethyl (2E,4E)-2-azido-5-(2,6-dimethoxyphenyl)penta-2,4-dienoate in the form of a yellow solid.

1. additionAdd dropwise
2. stirringAfter stirring at −10° C. for 3 h
3. stirringstir the reaction mixture for 15 h at RT
4. filtrationAfter filtration on a frit
5. washrinsing with 2×200 mL of water
6. dry with materialdry over Na2SO4
7. concentrationconcentrate under reduced pressure, which