Hydrochloric Acid → HCID 178479651, compound

HRID 1639957Notes

Reaction equation

HRID 1639957 reaction equation
[ClH:1].[OH:2][C@@H:3]1[CH2:8][CH2:7][C@H:6]([N:9]2[CH2:13][CH2:12][C:11]3([CH2:18][CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]3)[C:10]2=[O:26])[CH2:5][CH2:4]1>C(OCC)(=O)C>[ClH:1].[OH:2][C@@H:3]1[CH2:8][CH2:7][C@H:6]([N:9]2[CH2:13][CH2:12][C:11]3([CH2:18][CH2:17][CH2:16][NH:15][CH2:14]3)[C:10]2=[O:26])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451763HCID 178451763, compound

Product 1

HCID 178479651HCID 178479651, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Hydrogen chloride (2.0 mL, 4.0 M in 1,4-dioxane) was added to a solution of tert-butyl 2-(cis-4-hydroxycyclohexyl)-1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate (0.10 g) in ethyl acetate (0.5 mL) at room temperature and the mixture was stirred for 1 h. The solvent was then removed under vacuum to give the product. LC-MS: 253.2 (M+H)+.

Workup

  1. customThe solvent was then removed under vacuum
  2. customto give the product

Sources & evidence

ORD record
ord-e513f301ce6a46a7b9ffa4d9b5eddebd
Source dataset
uspto-grants-2012_02
Patent number
US08110581B2

Reaction notes

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