反应详情

43 mg (0.21 mmol) spiro[piperidine-4,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one were added to 50 mg (0.19 mmol) (6-chloro-pyrimidin-4-yl)-(2,3-dihydro-indol-1-yl)-methanone and 52 μL (0.58 mmol) DIPEA in 5 mL DMF. The reaction mixture was stirred for 2 h at RT. The reaction mixture was evaporated down using the rotary evaporator and the residue was mixed with 20 mL water and stirred for 30 min at RT. The product precipitated was suction filtered, stirred with diisopropylether and isopropanol, suction filtered and dried.

1. customThe reaction mixture was evaporated down
2. customthe rotary evaporator
3. additionthe residue was mixed with 20 mL water
4. stirringstirred for 30 min at RT
5. customThe product precipitated
6. filtrationfiltered
7. stirringstirred with diisopropylether and isopropanol, suction
8. filtrationfiltered
9. customdried