反应详情

温度

60 °C

Ethyl (2E)-[(2-fluorobenzyl)hydrazono]acetate (300 mg, 1.14 mmol) from example 1A are dissolved in ethyl acetate (2.0 ml). N-Chlorosuccinimide (143 mg, 1.07 mmol) is added, and the mixture is stirred at 60° C. for 1 h. It is then concentrated in vacuo, and the residue is stirred with carbon tetrachloride. The filtrate after filtration is concentrated. 292 mg (82% of theory) of the desired compound are obtained.

1. concentrationIt is then concentrated in vacuo
2. stirringthe residue is stirred with carbon tetrachloride
3. filtrationThe filtrate after filtration
4. concentrationis concentrated