Acetic Anhydride → HCID 86615839, compound

HRID 1640370Notes

Reaction equation

[CH2:1]([NH2:4])[C:2]#[CH:3].[C:5]1(=[O:11])O[C:8](=[O:9])[CH:7]=[CH:6]1.C(OC(=O)C)(=O)C.C([O-])(=O)C.[Na+]>>[C:5]1(=[O:11])[NH:4][C:8](=[O:9])[CH:7]=[CH:6]1.[CH2:1]([NH2:4])[C:2]#[CH:3]

Participants

Reactant 4

HCID 7918Acetic Anhydride

HCID 7923Maleic Anhydride

HCID 239041Propargylamine

HCID 517045Sodium Acetate

Product 1

HCID 86615839HCID 86615839, compound

Procedure

After the reaction of propargylamine and maleic anhydride in the presence of TEA, the intermediate acid was cyclized in the presence of acetic anhydride and sodium acetate at 70° C., to afford the desired propargylamine maleimide.

Sources & evidence

ORD record: ord-bee88a837a4948e98f72d634eb18a00c
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08114636B2

Reaction notes

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