Hydrochloric Acid → HCID 60209555, compound

HRID 1640410Notes

Reaction equation

HRID 1640410 reaction equation
[ClH:1].CC([CH:6]1[CH2:11][N:10](C([O-])=O)[CH2:9][CH2:8][N:7]1[C:15]([O:17][CH2:18][C:19]([NH:21][CH3:22])=[O:20])=[O:16])(C)C>C(O)(C)C.ClCCl>[ClH:1].[N:7]1([C:15]([O:17][CH2:18][C:19]([NH:21][CH3:22])=[O:20])=[O:16])[CH2:8][CH2:9][NH:10][CH2:11][CH2:6]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86609721HCID 86609721, compound

Product 1

HCID 60209555HCID 60209555, compound

Reagents, catalysts & solvents 2

HCID 3776IsopropanolSolventHCID 6344DichloromethaneSolvent

Procedure

25 ml of a 6N solution of hydrogen chloride in isopropanol are added to a solution of 2.68 g (8.9 mmol) of 2-(methylamino)-2-oxoethyl 1,1-dimethylethyl-1,4-piperazinedicarboxylate, obtained according to step 5.1, in 25 ml of dichloromethane. Stirring is continued at room temperature for 1 hour. The organic phase is removed by filtration through a hydrophobic cartridge and the acidic aqueous phase is concentrated under reduced pressure. After crystallization from isopropanol, 2.05 g of product are obtained in the form of a white solid, and are used without further purification in the following step.

Workup

  1. customobtained
  2. customThe organic phase is removed by filtration through a hydrophobic cartridge
  3. concentrationthe acidic aqueous phase is concentrated under reduced pressure
  4. customAfter crystallization from isopropanol, 2.05 g of product
  5. customare obtained in the form of a white solid
  6. customare used without further purification in the following step

Sources & evidence

ORD record
ord-e24fdffa7ffe49e5a0057a3b8cb34831
Source dataset
uspto-grants-2012_02
Patent number
US08114866B2

Reaction notes

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