Furfurylamine → N4-((furan-2-yl)methyl)-N6-(5-methyl-1H-pyrazol-3-yl)-2-styrylpyrimidine-4,6-diamine

HRID 1640439Notes

Reaction equation

HRID 1640439 reaction equation
CO[C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[CH:10][C:11]#[N:12])=[CH:5][CH:4]=1.[CH3:13][C:14]1[NH:18][N:17]=[C:16]([NH2:19])[CH:15]=1.[O:20]1[CH:24]=[CH:23][CH:22]=[C:21]1[CH2:25][NH2:26]>>[O:20]1[CH:24]=[CH:23][CH:22]=[C:21]1[CH2:25][NH:26][C:11]1[CH:10]=[C:9]([NH:19][C:16]2[CH:15]=[C:14]([CH3:13])[NH:18][N:17]=2)[N:12]=[C:11]([CH:10]=[CH:9][C:6]2[CH:5]=[CH:4][CH:3]=[CH:8][CH:7]=2)[N:12]=1

Participants

4

Reactant 3

HCID 3438FurfurylamineHCID 342403-(4-Methoxyphenyl)prop-2-enenitrileHCID 931461H-Pyrazol-3-amine, 5-methyl-

Product 1

HCID 86613127N4-((furan-2-yl)methyl)-N6-(5-methyl-1H-pyrazol-3-yl)-2-styrylpyrimidine-4,6-diamine

Procedure

Example 162 was synthesized via Scheme 6 according to the general scheme provided above with the appropriate starting materials 3-(4-methoxyphenyl)acrylonitrile, 5-methyl-1H-pyrazole-3-amine, and (furan-2-yl)methanamine. Structure of the target was confirmed by 1H-NMR. The 1H-NMR is attached.

Workup

  1. customExample 162 was synthesized via Scheme 6 according to the general scheme
  2. customprovided above with the

Sources & evidence

ORD record
ord-277a480dda3c4dd49d931db364614aad
Source dataset
uspto-grants-2012_02
Patent number
US08114870B2

Reaction notes

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