Ammonium Hydroxide → Diethylether ethylacetate

HRID 1640532Notes

Reaction equation

[NH4+].[OH-].[CH3:3][C:4](=[O:8])[O:5][CH2:6][CH3:7].CO>>[CH3:3][C:4](=[O:8])[O:5][CH2:6][CH3:7].[CH3:3][CH2:4][O:5][CH2:6][CH3:7]

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 21584119Ethylacetate methanol

Product 1

HCID 21584169Diethylether ethylacetateYield 13%

Procedure

Intermediate 111.i (0.08 g, 0.35 mmol) and intermediate 4.v (0.097 g, 1 eq.) were coupled according to method J. The title compound was isolated after FC (EA/MeOH 9:1+1% NH4OH) and crystallization from EA/ether as a colourless solid (0.022 g, 13% yield).

Sources & evidence

ORD record: ord-e54b40fcceb74a71b967b14382ef11a9
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08114867B2

Reaction notes

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