Potassium Phosphate, Tribasic → 5-Cyclopropyl-2-fluoropyridine

HRID 1640878Notes

Reaction equation

HRID 1640878 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][N:3]=1.[CH:9]1(B(O)O)[CH2:11][CH2:10]1.P([O-])([O-])([O-])=O.[K+].[K+].[K+]>C1(C)C=CC=CC=1.O.C(Cl)(Cl)Cl.CC(O)C.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[CH:9]1([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[N:3][CH:4]=2)[CH2:11][CH2:10]1

Participants

7

Reactant 3

HCID 62657Potassium Phosphate, TribasicHCID 2760897Cyclopropylboronic acidHCID 27831792-Fluoro-5-iodopyridine

Product 1

HCID 576908315-Cyclopropyl-2-fluoropyridineYield 63%

Reagents, catalysts & solvents 3

HCID 167845palladium(II) acetateCatalystHCID 21906603Chloroform isopropyl alcoholSolventHCID 22272177Toluene waterSolvent

Conditions

Temperature
100 °C

Procedure

Combine 2-fluoro-5-iodo-pyridine (1.12 g, 5 mmol), cyclopropylboronic acid (645 mg, 7.5 mmol), palladium acetate (56 mg, 0.25 mmol) and potassium phosphate (3.2 g, 15 mmol) in toluene/water (20:1, 21 mL). Heat the mixture at 100° C. for 4 h. Dilute the mixture with chloroform-IPA (3:1, 100 mL). Wash the organic phase with saturated aqueous sodium chloride and water. Dry the mixture over sodium sulfate. Concentrate the solution in vacuo to a brown oil. Purify by column chromatography (20% ethyl acetate in hexane) to afford the title compound as a pale yellow oil (430 mg, 63%).

Workup

  1. washWash the organic phase with saturated aqueous sodium chloride and water
  2. dry with materialDry the mixture over sodium sulfate
  3. concentrationConcentrate the solution in vacuo to a brown oil
  4. customPurify by column chromatography (20% ethyl acetate in hexane)

Sources & evidence

ORD record
ord-5d9416ce72c24ad2b8a521cb9df9c9c3
Source dataset
uspto-grants-2012_02
Patent number
US08114872B2

Reaction notes

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