反应详情

温度

50 °C

2.40 g (5.37 mmol) of 1-benzofuran-4-ol (from example XXI), 0.90 g (5.64 mmol) of 3,4-difluoronitrobenzene and 1.48 g (10.7 mmol) of potassium carbonate are suspended in 20 ml of anhydrous dimethylformamide, and the mixture is stirred at 50° C. for 5 hours. The reaction solution is then diluted with water and extracted twice with ethyl acetate. The combined organic phases are dried over sodium sulfate. The solvent is removed under reduced pressure. The crude product is purified on a silica gel column (mobile phase: cyclohexane:ethyl acetate (10:1)).

1. extractionextracted twice with ethyl acetate
2. dry with materialThe combined organic phases are dried over sodium sulfate
3. customThe solvent is removed under reduced pressure
4. customThe crude product is purified on a silica gel column (mobile phase: cyclohexane:ethyl acetate (10:1))