反应详情

温度

50 °C

100 mg (0.75 mmol) of 1H-indazol-4-ol (from example XXIV), 94 mg (0.64 mmol) of 3,4-difluoronitrobenzene and 103 mg (0.75 mmol) of potassium carbonate are suspended in 2 ml of anhydrous dimethylformamide, and the mixture is stirred at 50° C. for 5 hours. The reaction solution is then diluted with water and extracted 2× with ethyl acetate. The combined organic phases are dried over sodium sulfate. The solvent is removed under reduced pressure. The crude product is purified by preparative HPLC.

1. extractionextracted 2× with ethyl acetate
2. dry with materialThe combined organic phases are dried over sodium sulfate
3. customThe solvent is removed under reduced pressure
4. customThe crude product is purified by preparative HPLC