4-Cyanobenzoic acid → 4-Cyano-N-[4-(2-morpholin-4-ylethoxy)-1-naphthyl]benzamide
Reaction equation
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][CH:4]=1)#[N:2].[N:12]1([CH2:18][CH2:19][O:20][C:21]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:24]([NH2:31])=[CH:23][CH:22]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:7]([NH:31][C:24]2[C:25]3[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:21]([O:20][CH2:19][CH2:18][N:12]3[CH2:13][CH2:14][O:15][CH2:16][CH2:17]3)=[CH:22][CH:23]=2)=[O:9])=[CH:10][CH:11]=1)#[N:2]Participants
3
Procedure
Compound is prepared from 4-cyanobenzoic acid and 4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-ylamine according to conditions described in general procedure G. Mp: 213-214° C.; 1H NMR (300 MHz, CDCl3) δ 2.70 (m, 4H), 3.00 (t, 2H), 3.78 (t, 4H), 4.35 (t, 2H), 6.80 (d, 1H), 7.50-7.70 (m, 5H), 7.80 (d, 1H), 7.95 (d, 2H), 8.31 (s, 2H); MS 402 (M+1).
Sources & evidence
- ORD record
- ord-f344e0263b234f548f461274d9ee6139
- Source dataset
- uspto-grants-2012_02
- Patent number
- US08114873B2
Reaction notes
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