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HRID1641329

反应详情

EQUATION

反应方程式

HRID 1641329 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：Clc1nc(Cl)c2c(n1)CCS2
HCID45789967

2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

C6H4Cl2N2S

结构：CC(C)[C@@H](N)C(N)=O.Cl
HCID53486046

D-Valinamide--hydrogen chloride (1/1)

C5H13ClN2O

PRODUCTS

生成物

1
结构：CC(C)[C@@H](Nc1nc(Cl)nc2c1SCC2)C(N)=O
HCID59708380

未命名化合物

收率 74%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

CONDITIONS

反应条件

温度
120 °C

PROCEDURE

实验过程

800 mg 2,4-dichloro-6,7-dihydro-thieno[3,2-d]pyrimidine and 800 mg D-valinamide hydrochloride are placed in 8 ml dioxane, then 2.7 ml diisopropylethylamine are added. The reaction mixture is heated to 120° C. in the microwave for 2 hours. The residue is mixed with water. The precipitate formed is suction filtered and dried. 820 mg of the product are obtained as a powder. Analytical HPLC (method B): RT=2.64 min.

WORKUP

后处理

  1. customThe precipitate formed
  2. filtrationfiltered
  3. customdried