反应详情

温度

70 °C

1.0 g of N-(4-chloro-2-(1-cyclopropylethylcarbamoyl)phenyl)-5-oxopyrazolidine-3-carboxamide was dissolved in 10 ml of N,N-dimethylformamide, 460 mg of 2,3-dichloropyridine was added and then 350 mg of sodium hydride was added, followed by stirring for about 7 hours at about 70° C. in nitrogen atmosphere, and the reaction liquid was stood to cool. Water was added to the reaction liquid and stirred, followed by extraction with ethyl acetate, and the obtained crude product was purified by silica gel column chromatography (eluent: ethyl acetate/methanol=9/1) to obtain 1.15 g of the desired product.

1. customthe reaction liquid
2. temperatureto cool
3. stirringstirred
4. extractionfollowed by extraction with ethyl acetate
5. customthe obtained crude product
6. customwas purified by silica gel column chromatography (eluent: ethyl acetate/methanol=9/1)