Methanol → HCID 86761491, compound

HRID 1641485Notes

Reaction equation

[CH3:1][C:2]1[N:3]([CH2:41][CH2:42][CH2:43][C:44]([O-:46])=[O:45])[C:4]2[C:9]([C:10]=1[CH2:11][CH2:12][CH2:13][C:14]([O-:16])=[O:15])=[CH:8][CH:7]=[CH:6][C:5]=2[C:17]#[C:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]2[C:35]([F:36])=[C:34]([F:37])[C:33]([F:38])=[C:32]([F:39])[C:31]=2[F:40])=[CH:21][CH:20]=1.[Na+:47].[Na+].C[OH:50].CC([OH:54])C>O>[OH2:15].[OH2:54].[OH2:50].[CH3:1][C:2]1[N:3]([CH2:41][CH2:42][CH2:43][C:44]([O-:46])=[O:45])[C:4]2[C:9]([C:10]=1[CH2:11][CH2:12][CH2:13][C:14]([O-:16])=[O:15])=[CH:8][CH:7]=[CH:6][C:5]=2[C:17]#[C:18][C:19]1[CH:20]=[CH:21][C:22]([O:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]2[C:35]([F:36])=[C:34]([F:37])[C:33]([F:38])=[C:32]([F:39])[C:31]=2[F:40])=[CH:23][CH:24]=1.[Na+:47].[Na+:47]

Participants

Conditions

Temperature: 5 °C

Procedure

The compound (10 g) prepared in Example 57 was dissolved in water (40 mL) and methanol (40 mL) at 53° C. To the solution, 2-propanol (1900 mL) was added and cooled to 5° C. The precipitated solid was filtered and dried at 40° C. under reduced pressure. The compound was maintained at 60% of relative humidity at 25° C. for 2 days to obtain the title compound (8.2 g) having the following physical properties.

Workup

customat 53° C
filtrationThe precipitated solid was filtered
customdried at 40° C. under reduced pressure
temperatureThe compound was maintained at 60% of relative humidity at 25° C. for 2 days

Sources & evidence

ORD record: ord-44ec4b00067d4cdd98c21fecc961eda5
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08115014B2

Reaction notes

Loading…