Hydrochloric Acid → HCID 46206104, compound

HRID 1641543Notes

Reaction equation

HRID 1641543 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][C:23]2([NH:31]C(=O)C)[CH2:28][O:27]C(C)(C)[O:25][CH2:24]2)=[CH:17][CH:16]=1.[ClH:35]>CO>[ClH:35].[NH2:31][C:23]([CH2:22][CH2:21][C:18]1[CH:17]=[CH:16][C:15]([C:3]2[CH:4]=[CH:5][C:6]([S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)=[CH:7][C:2]=2[F:1])=[CH:20][CH:19]=1)([CH2:28][OH:27])[CH2:24][OH:25]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57624596HCID 57624596, compound

Product 1

HCID 46206104HCID 46206104, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
70 °C

Procedure

N-(5-{2-[2′-Fluoro-4′-(phenylthio)biphenyl-4-yl]ethyl}-2,2-dimethyl-1,3-dioxan-5-yl)acetamide (468 mg) was dissolved in methanol (6 mL), concentrated hydrochloric acid (3 mL) was added, and the mixture was stirred at 70° C. for 3.5 hr. The reaction mixture was concentrated, and the residual crude crystals were suspended in diisopropyl ether and collected by filtration to give the title compound (329 mg) as white crystals.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. filtrationcollected by filtration

Sources & evidence

ORD record
ord-f2a677ed0ac048b5899a0ba55e7fb5ea
Source dataset
uspto-grants-2012_02
Patent number
US08114902B2

Reaction notes

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