Hydrochloric Acid → HCID 24852497, compound

HRID 1641560Notes

Reaction equation

HRID 1641560 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][C:25]2([NH:33]C(=O)C)[CH2:30][O:29]C(C)(C)[O:27][CH2:26]2)=[CH:19][CH:18]=1.[ClH:37]>C(O)C>[ClH:37].[NH2:33][C:25]([CH2:24][CH2:23][C:20]1[CH:19]=[CH:18][C:17]([C:3]2[CH:4]=[CH:5][C:6]([S:8][C:9]3[CH:10]=[CH:11][C:12]([O:15][CH3:16])=[CH:13][CH:14]=3)=[CH:7][C:2]=2[F:1])=[CH:22][CH:21]=1)([CH2:30][OH:29])[CH2:26][OH:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 24852385HCID 24852385, compound

Product 1

HCID 24852497HCID 24852497, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

N-(5-{2-[2′-Fluoro-4′-(4-methoxyphenylthio)biphenyl-4-yl]ethyl}-2,2-dimethyl-1,3-dioxan-5-yl)acetamide (0.22 g) was dissolved in ethanol (4 mL), concentrated hydrochloric acid (2 mL) was added, and the mixture was stirred at 75° C. for 4 hr. The reaction mixture was concentrated to dryness, and the residual solid was suspended in ethyl acetate and collected by filtration to give the title compound (39 mg) as brown crystals.

Workup

  1. concentrationThe reaction mixture was concentrated to dryness
  2. filtrationcollected by filtration

Sources & evidence

ORD record
ord-23e52cd10b8747f1bac4984c1d05f980
Source dataset
uspto-grants-2012_02
Patent number
US08114902B2

Reaction notes

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