Sodium ion → 2-[4-(4-Bromo-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-4-(2-methoxy-ethoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 164170Notes

Reaction equation

HRID 164170 reaction equation
[Br:36][CH2:37][CH2:38][O:39][CH3:40].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([c:14]2[n:15]([CH2:26][O:27][CH2:28][CH2:29][Si:30]([CH3:31])([CH3:32])[CH3:33])[cH:16][c:17](-[c:19]3[cH:20][cH:21][c:22]([Br:25])[cH:23][cH:24]3)[n:18]2)[CH2:10][CH:11]([OH:13])[CH2:12]1.[H-:35].[Na+:34].[O:41]=[CH:42][N:43]([CH3:44])[CH3:45]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([c:14]2[n:15]([CH2:26][O:27][CH2:28][CH2:29][Si:30]([CH3:31])([CH3:32])[CH3:33])[cH:16][c:17](-[c:19]3[cH:20][cH:21][c:22]([Br:25])[cH:23][cH:24]3)[n:18]2)[CH2:10][CH:11]([O:13][CH2:37][CH2:38][O:39][CH3:40])[CH2:12]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 6228DimethylformamideHCID 809722-Bromoethyl methyl etherHCID 166653HydrideHCID 666211532-[4-(4-Bromo-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 666212672-[4-(4-Bromo-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-4-(2-methoxy-ethoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-d60599f9dd384bd3882990f2df12f255
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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