反应详情

To a solution of 5-[(2,5-difluorophenyl)[(4-fluorophenyl)sulfonyl]methyl]-4-methylpyridine-2-carboxamide (150 mg, 0.33 mmol) obtained in Example 15 in N,N-dimethylformamide (3 ml), a formaldehyde solution (37%, 54 μl) and dimethylamine hydrochloride (136 mg, 1.67 mmol) were added at 0° C., and the mixture was stirred for 2 hours at room temperature. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate, and was dried over anhydrous sodium sulfate. The solvent was concentrated under reduced pressure, and the resulting residue was subjected to silica gel chromatography. The fraction obtained from an elution with dichloromethane:methanol=10:1 was concentrated under reduced pressure, and the resulting residue was washed with diethyl ether and dichloromethane and dried, to obtain the title compound (99 mg, 0.21 mmol, 63%) as a white solid.

1. extractionthe mixture was extracted with ethyl acetate
2. dry with materialwas dried over anhydrous sodium sulfate
3. concentrationThe solvent was concentrated under reduced pressure
4. customThe fraction obtained from an elution with dichloromethane
5. concentrationmethanol=10:1 was concentrated under reduced pressure
6. washthe resulting residue was washed with diethyl ether and dichloromethane
7. customdried