Tetrahydrofuran → tert-butyl N-(5-formyl-1,3-thiazol-2-yl)carbamate

Temperature

-10 °C

To a solution of 2-tert-butyloxycarbonylaminothiazole (88.0 g, 439 mmol) in THF (1760 ml) was added dropwise a 1.59M solution of n-butyllithium in hexane (729 ml, 1159 mmol) over 20 minutes at −78° C., and the mixture was warmed to −10° C. over 1 hour. The mixture was cooled again to −78° C. and thereto was added DMF (102 ml, 0.132 mmol) in one portion. The acetonedry ice bath was removed. The mixture was stirred for 30 minutes, and then poured into cold water (1000 ml) and thereto was added ethyl acetate (2000 ml). The organic layer was washed sequentially with water and brine, dried over anhydrous magnesium sulfate and the solvents were removed. The residue was recrystallized from ethyl acetate to give 2-tert-butyloxycarbonylaminothiazole-5-carbaldehyde (74.8 g).

1. temperatureThe mixture was cooled again to −78° C.
2. customThe acetonedry ice bath was removed
3. additionpoured into cold water (1000 ml)
4. additionwas added ethyl acetate (2000 ml)
5. washThe organic layer was washed sequentially with water and brine
6. dry with materialdried over anhydrous magnesium sulfate
7. customthe solvents were removed
8. customThe residue was recrystallized from ethyl acetate

ORD record

ord-b302105faad24836b5ba82f44c312c1c

Source dataset

uspto-grants-2012_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08119626B2