反应详情

KCN (0.17 mol) and morpholine (14.7 g, 0.17 mol) were added to a solution of 1,4-dioxa-spiro[4.5]decane-8-carboxaldehyde (0.141 mol) in a mixture of ethanol (141 ml) and water (70 ml), and stirring was carried out for 72 h at 25° C. After addition of ethyl acetate (700 ml), the organic phase was separated off and washed in succession with water (4×150 ml) and aqueous FeSO4 solution (4×150 ml). The organic phase was separated off and dried over Na2SO4 and then filtered off. The solvent was removed in vacuo, and the product was used in the next stage without being purified further.

1. customthe organic phase was separated off
2. washwashed in succession with water (4×150 ml) and aqueous FeSO4 solution (4×150 ml)
3. customThe organic phase was separated off
4. dry with materialdried over Na2SO4
5. filtrationfiltered off
6. customThe solvent was removed in vacuo
7. customwithout being purified further