Water → HCID 66703325, compound

HRID 1642107Notes

Reaction equation

HRID 1642107 reaction equation
[N:1]1([CH:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:8]2[CH2:13][CH2:12][C:11](=[N:14]O)[CH2:10][CH2:9]2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>O1CCCC1>[N:1]1([CH:7]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:8]2[CH2:9][CH2:10][CH:11]([NH2:14])[CH2:12][CH2:13]2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 86625454HCID 86625454, compound

Product 1

HCID 66703325HCID 66703325, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 4-(morpholin-4-yl-phenylmethyl)cyclohexanone oxime (1.20 g, 4.16 mmol) in absolute tetrahydrofuran (12 ml) was added dropwise at 60° C., under argon, to a suspension of lithium aluminium hydride (316 mg, 8.32 mmol) in absolute tetrahydrofuran (40 ml), and stirring was carried out for 4 h at that temperature. After cooling, water (1.5 ml) and 4 N sodium hydroxide solution (0.4 ml) were added dropwise. The suspension was filtered, and the filtrate was dried over sodium sulfate and concentrated in vacuo.

Workup

  1. temperatureAfter cooling
  2. filtrationThe suspension was filtered
  3. dry with materialthe filtrate was dried over sodium sulfate
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-e14ecc74835d4577b6ed4357de23a30c
Source dataset
uspto-grants-2012_02
Patent number
US08119633B2

Reaction notes

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