Ethylenediamine → Ethyl 2-(3-oxopiperazin-2-yl)acetate

HRID 1642139Notes

Reaction equation

HRID 1642139 reaction equation
[CH2:1]([NH2:4])[CH2:2][NH2:3].[C:5]([O:14][CH2:15][CH3:16])(=[O:13])/[CH:6]=[CH:7]\[C:8]([O:10]CC)=O>C(O)CC>[O:10]=[C:8]1[NH:4][CH2:1][CH2:2][NH:3][CH:7]1[CH2:6][C:5]([O:14][CH2:15][CH3:16])=[O:13]

Participants

4

Reactant 2

HCID 3301EthylenediamineHCID 5271566Diethyl Maleate

Product 1

HCID 544550Ethyl 2-(3-oxopiperazin-2-yl)acetate

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

Ethylenediamine (1.17 ml, 17.42 mmol) and diethyl maleate (3 g, 17.42 mmol) were stirred for 16 h at 55° C. in propanol (30 ml). The solvent was removed in vacuo and the residue was dried in vacuo. The product was used in the next stage without being purified further.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue was dried in vacuo
  3. customwithout being purified further

Sources & evidence

ORD record
ord-aa117c5babde45f4804c22ff5604f474
Source dataset
uspto-grants-2012_02
Patent number
US08119633B2

Reaction notes

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