Lithium Hydroxide → HCID 22390716, compound

HRID 1642142Notes

Reaction equation

HRID 1642142 reaction equation
[OH-].[Li+].[Cl:3][C:4]1[CH:5]=[C:6]([S:11]([N:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[NH:17][C:16](=[O:24])[CH:15]2[CH2:25][C:26]([O:28]C)=[O:27])(=[O:13])=[O:12])[CH:7]=[CH:8][C:9]=1[Cl:10]>C1COCC1.O>[Cl:3][C:4]1[CH:5]=[C:6]([S:11]([N:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[NH:17][C:16](=[O:24])[CH:15]2[CH2:25][C:26]([OH:28])=[O:27])(=[O:13])=[O:12])[CH:7]=[CH:8][C:9]=1[Cl:10]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 66756475HCID 66756475, compound

Product 1

HCID 22390716HCID 22390716, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

Lithium hydroxide (0.041 g, 10.95 mmol) was added to a cooled solution of methyl 2-(1-(3,4-dichlorophenylsulfonyl)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetate (2.7 g, 7.3 mmol) in THF (45 ml) and water (45 ml), and stirring was carried out for 48 h at room temperature (TLC monitoring). The solvent was removed using a rotary evaporator and the residue was taken up in water. The aqueous phase was extracted with ethyl acetate and then washed with saturated NaCl solution. The organic phase was dried over sodium sulfate and concentrated to dryness.

Workup

  1. customThe solvent was removed
  2. customa rotary evaporator
  3. extractionThe aqueous phase was extracted with ethyl acetate
  4. washwashed with saturated NaCl solution
  5. dry with materialThe organic phase was dried over sodium sulfate
  6. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-abd9030eca69461bb22c101bb379c811
Source dataset
uspto-grants-2012_02
Patent number
US08119633B2

Reaction notes

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