反应详情

温度

40 °C

A mixture of 2-methylquinolin-6-amine (2.4 g, 15.2 mmol) and NaH (2.4 g, 60.8 mmol) in DMF (60 mL) was stirred at 40° C. for 3 hrs. Then CH3I (3.8 mL, 60.8 mmol) was added by syringe. The reaction mixture was stirred at 40° C. overnight and then cooled to room temperature. The reaction mixture was diluted with water and extracted with EtOAc. The organic layer was washed with water and brine and dried over anhydrous Na2SO4. After purified by column chromatography (hexane/EtOAc=25:1), compound 3 was obtained (1.1 g, 39%). MS [M++1]=187, LC-MS: tR=0.775 min.

1. stirringThe reaction mixture was stirred at 40° C. overnight
2. temperaturecooled to room temperature
3. extractionextracted with EtOAc
4. washThe organic layer was washed with water and brine
5. dry with materialdried over anhydrous Na2SO4
6. customAfter purified by column chromatography (hexane/EtOAc=25:1)