HCID 57619809, compound → HCID 55288821, compound

HRID 1642494Notes

Reaction equation

HRID 1642494 reaction equation
[C:1]([CH2:3][C@H:4]1[CH2:9][CH2:8][CH2:7][CH2:6][C@@H:5]1[NH:10]C(=O)OC(C)(C)C)#[N:2]>CO.Cl.O1CCOCC1>[NH2:10][C@H:5]1[CH2:6][CH2:7][CH2:8][CH2:9][C@@H:4]1[CH2:3][C:1]#[N:2]

Participants

5

Reactant 1

HCID 57619809HCID 57619809, compound

Product 1

HCID 55288821HCID 55288821, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution tert-butyl N-[(1S,2R)-2-(cyanomethyl)cyclohexyl]carbamate (2 g) in MeOH (40 mL) and 4 M HCl in dioxane (20 mL) was stirred at room temperature for 2 hours and concentrated in vacuo to provide the title compound as a yellow oil, which was used for the subsequent step without further purification.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-5d866fdb39624dafadd68d6fe0a7198a
Source dataset
uspto-grants-2012_02
Patent number
US08119661B2

Reaction notes

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