HCID 57619803, compound → HCID 57619825, compound

HRID 1642497Notes

Reaction equation

HRID 1642497 reaction equation
[O:1]=[C:2]1[CH2:10][C@@H:9]2[C@H:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[N:3]1[CH:11]1[CH2:16][CH2:15][N:14]([C:17]2([CH3:30])[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)[CH2:13][CH2:12]1>CO.Cl.O1CCOCC1>[CH3:30][C:17]1([N:14]2[CH2:15][CH2:16][CH:11]([N:3]3[C@@H:4]4[C@H:9]([CH2:8][CH2:7][CH2:6][CH2:5]4)[CH2:10][C:2]3=[O:1])[CH2:12][CH2:13]2)[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]1

Participants

5

Reactant 1

HCID 57619803HCID 57619803, compound

Product 1

HCID 57619825HCID 57619825, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of tert-butyl 4-[4-[(3aR,7aS)-2-oxo-3a,4,5,6,7,7a-hexahydro-3H-indol-1-yl]-1-piperidyl]-4-methyl-piperidine-1-carboxylate in MeOH (14 mL) and 4M HCl in dioxane (5 mL) was stirred at room temperature overnight. Concentrated in vacuo and the residue was purified by preparative LC/MS (high pH) to provide the title compound as a colorless oil (0.41 g). MS (M+1): 320.30.

Workup

  1. concentrationConcentrated in vacuo
  2. customthe residue was purified by preparative LC/MS (high pH)

Sources & evidence

ORD record
ord-2ee4748b80764c089caf464055e4b8df
Source dataset
uspto-grants-2012_02
Patent number
US08119661B2

Reaction notes

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