Triethylamine → HCID 57374593, compound

HRID 1642819Notes

Reaction equation

HRID 1642819 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[C:8]#[N:9].[Cl-].[OH:11][NH3+:12].C(N(CC)CC)C>>[OH:11][N:12]=[C:8]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:2]=1[CH3:1])[NH2:9]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 21645Hydroxylamine HClHCID 2278064-Methyl-3-cyanopyridine

Product 1

HCID 57374593HCID 57374593, compound

Procedure

850 mg (7.20 mmol) of 4-methylpyridine-3-carbonitrile, 750 mg (10.79 mmol) of hydroxylammonium chloride and 1.2 ml (8.6 mmol) of triethylamine were reacted according to the General Method 5A. Yield: 666 mg (61% of theory)

Sources & evidence

ORD record
ord-0971bb7babbf45ed8c3e87555cbdd073
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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