Hydrochloric Acid → HCID 66755065, compound

HRID 1642975Notes

Reaction equation

HRID 1642975 reaction equation
[ClH:1].C(OC(=O)[NH:8][C:9]([C:12]1[O:16][N:15]=[C:14]([CH:17]2[CH2:22][CH:21]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=3)[CH2:20][N:19]([C:33]([N:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)=[O:34])[CH2:18]2)[N:13]=1)([CH3:11])[CH3:10])(C)(C)C>O1CCOCC1>[ClH:1].[NH2:8][C:9]([C:12]1[O:16][N:15]=[C:14]([CH:17]2[CH2:22][CH:21]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:31])([F:32])[F:30])=[CH:25][CH:24]=3)[CH2:20][N:19]([C:33]([N:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)=[O:34])[CH2:18]2)[N:13]=1)([CH3:11])[CH3:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58002498HCID 58002498, compound

Product 1

HCID 66755065HCID 66755065, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

0.12 ml (0.50 mmol) of a 4N solution of hydrogen chloride in dioxane was added to a solution of 29 mg (about 0.05 mmol) of the compound from Example 86A in 0.2 ml of dioxane. The reaction mixture was stirred at room temperature for 20 hours. The mixture was then concentrated to dryness under reduced pressure and dried until the weight remained constant. Yield: 24 mg (96% of theory).

Workup

  1. concentrationThe mixture was then concentrated to dryness under reduced pressure
  2. customdried until the weight

Sources & evidence

ORD record
ord-dc98869aad1d40e1bf6ec8e142177480
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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