Hydrochloric Acid → HCID 66755645, compound

HRID 1642976Notes

Reaction equation

HRID 1642976 reaction equation
[ClH:1].C(OC(=O)[NH:8][C@H:9]([C:11]1[O:15][N:14]=[C:13]([CH:16]2[CH2:21][CH:20]([C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=3)[CH2:19][N:18]([C:32]([N:34]3[CH2:39][CH2:38][O:37][CH2:36][CH2:35]3)=[O:33])[CH2:17]2)[N:12]=1)[CH3:10])(C)(C)C>O1CCOCC1>[ClH:1].[NH2:8][C@H:9]([C:11]1[O:15][N:14]=[C:13]([CH:16]2[CH2:21][CH:20]([C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:29])([F:30])[F:31])=[CH:24][CH:23]=3)[CH2:19][N:18]([C:32]([N:34]3[CH2:39][CH2:38][O:37][CH2:36][CH2:35]3)=[O:33])[CH2:17]2)[N:12]=1)[CH3:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58002140HCID 58002140, compound

Product 1

HCID 66755645HCID 66755645, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

0.11 ml (0.45 mmol) of a 4N solution of hydrogen chloride in dioxane was added to a solution of 25 mg (0.05 mmol) of the compound from Example 88A in 0.2 ml of dioxane. The reaction mixture was stirred at room temperature for 20 hours. The mixture was then concentrated to dryness under reduced pressure and dried until the weight remained constant. Yield: 20 mg (93% of theory).

Workup

  1. concentrationThe mixture was then concentrated to dryness under reduced pressure
  2. customdried until the weight

Sources & evidence

ORD record
ord-a403baab6b174cc28b2684e04ad4d8ce
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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